The association of growth differentiation factor 5 rs143383 gene polymorphism with osteoarthritis: a systematic review and meta-analysis.

ABSTRACT:

Background

Osteoarthritis (OA) is caused by a complex set of pathophysiological factors. The genetic factors involved in the occurrence and progress of the disease have been widely discussed by scholars. It was found that growth differentiation factor 5 (GDF5) gene polymorphisms may be linked to OA susceptibility, which has been controversial and needs to be further confirmed by an updated meta-analysis.

Objectives

We examined the association between GDF5 rs143383 single nucleotide polymorphism (SNP) and OA susceptibility.

Methods

All relevant articles that met the criteria are retrieved and included, and the search deadline is June 2022. The allele frequencies and different genotype frequencies of GDF5 rs143383 loci in each study were extracted and statistically anal

SUBMITTER: Wang YP 

PROVIDER: S-EPMC10563324 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature