Matrix density regulates adipocyte phenotype.
Ontology highlight
ABSTRACT:
SUBMITTER: Ky A
PROVIDER: S-EPMC10566443 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Publications
Matrix density regulates adipocyte phenotype.
Ky Alexander A McCoy Atticus J AJ Flesher Carmen G CG Friend Nicole E NE Li Jie J Akinleye Kore K Patsalis Christopher C Lumeng Carey N CN Putnam Andrew J AJ O'Rourke Robert W RW
Adipocyte 20231010 1
Alterations of the extracellular matrix contribute to adipose tissue dysfunction in metabolic disease. We studied the role of matrix density in regulating human adipocyte phenotype in a tunable hydrogel culture system. Lipid accumulation was maximal in intermediate hydrogel density of 5 weight %, relative to 3% and 10%. Adipogenesis and lipid and oxidative metabolic gene pathways were enriched in adipocytes in 5% relative to 3% hydrogels, while fibrotic gene pathways were enriched in 3% hydrogel ...[more]
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