Visible light-triggered selective C(sp²)-H/C(sp³)-H coupling of benzenes with aliphatic hydrocarbons.

ABSTRACT: The direct and selective coupling of benzenes with aliphatic hydrocarbons is a promising strategy for C(sp²)-C(sp³) bond formation using readily available starting materials, yet it remains a significant challenge. In this study, we have developed a simplified photochemical system that incorporates catalytic amounts of iron(III) halides as multifunctional reagents and air as a green oxidant to address this synthetic problem. Under mild conditions, the reaction between a strong C(sp²)-H bond and a robust C(sp³)-H bond has been achieved, affording a broad range of cross-coupling products with high yields and commendable chemo-, site-selectivity. The iron halide acts as a multifunctional reagent that responds to visible light, initiates C-centered r

SUBMITTER: Li QY 

PROVIDER: S-EPMC10567795 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature