Fate and distribution of orally-ingested CeO₂-nanoparticles based on a mouse model: Implication for human health.

ABSTRACT: The use of nanoparticles in agrichemical formula and food products as additives has increased their chances of accumulation in humans via oral intake. Due to their potential toxicity, it is critical to understand their fate and distribution following oral intake. Cerium oxide nanoparticle (CeO₂NP) is commonly used in agriculture and is highly stable in the environment. As such, it has been used as a model chemical to investigate nanoparticle's distribution and clearance. Based on their estimated human exposure levels, 0.15-0.75 mg/kg body weight/day of CeO₂NPs with different sizes and surface charges (30-50 nm with negative charge and <25 nm with positive charge) were gavaged into C57BL/6 female mice daily. After 10-d, 50% of mice in each treatment were terminated, wi

SUBMITTER: Ma X 

PROVIDER: S-EPMC10568217 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature