The potential DNA methylation markers of cardiovascular disease in patients with type 2 diabetes.

ABSTRACT:

Background

DNA methylation is associated with cardiovascular (CV) disease. However, in type 2 diabetes (T2D) patients, the role of gene methylation in the development of CV disease is under-studied. We aimed to identify the CV disease-related DNA methylation loci in patients with T2D and to explore the potential pathways underlying the development of CV disease using a two-stage design.

Methods

The participants were from the Jinan Diabetes Cohort Study (JNDCS), an ongoing longitudinal study designed to evaluate the development of CV risk in patients with T2D. In the discovery cohort, 10 diabetic patients with CV events at baseline were randomly selected as the case group, and another 10 diabetic patients without CV events were matched for sex, age, smoking status, and body m

SUBMITTER: He Y 

PROVIDER: S-EPMC10568935 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature