Risk of osteoporosis in patients treated with direct oral anticoagulants vs. warfarin: an analysis of observational studies.

ABSTRACT:

Aims

Evidence on the association between the risk of new-onset osteoporosis and oral anticoagulants remains controversial. We aimed to compare the risk of osteoporosis associated with the use of direct oral anticoagulants (DOACs) with that associated with warfarin use.

Methods

Studies published up to 15 March 2023 that investigated the association between the use of DOACs and warfarin and the incidence of osteoporosis were identified by online searches in PubMed, Embase, the Cochrane Library, and Web of Science conducted by two independent investigators. Random-effects or fixed-effect models were employed to synthesize hazard ratios (HRs)/relative ratios (RRs) with 95% confidence intervals (CIs) for estimating the risk of osteoporosis correlated with DOAC and warfarin prescr

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10570517 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature