Ontology highlight
ABSTRACT:
SUBMITTER: Sarkar B
PROVIDER: S-EPMC10571100 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Sarkar Biplab B Ma Xiaotang X Agas Agnieszka A Siddiqui Zain Z Iglesias-Montoro Patricia P Nguyen Peter K PK Kim Ka Kyung KK Haorah James J Kumar Vivek A VA
Chemical engineering journal (Lausanne, Switzerland : 1996) 20201009
Traumatic brain injury (TBI) is associated with poor intrinsic healing responses and long-term cognitive decline. A major pathological outcome of TBI is acute glutamate-mediated excitotoxicity (GME) experienced by neurons. Short peptides based on the neuroprotective extracellular glycoprotein ependymin have shown the ability to slow down the effect of GME - however, such short peptides tend to diffuse away from target sites after <i>in vivo</i> delivery. We have designed a self-assembling peptid ...[more]