The Involvement of Neuroinflammation in the Onset and Progression of Parkinson's Disease.

ABSTRACT: Parkinson's disease is a neurodegenerative disease exhibiting the fastest growth in incidence in recent years. As with most neurodegenerative diseases, the pathophysiology is incompletely elucidated, but compelling evidence implicates inflammation, both in the central nervous system and in the periphery, in the initiation and progression of the disease, although it is not yet clear what triggers this inflammatory response and where it begins. Gut dysbiosis seems to be a likely candidate for the initiation of the systemic inflammation. The therapies in current use provide only symptomatic relief, but do not interfere with the disease progression. Nonetheless, animal models have shown promising results with therapies that target various vicious neuroinflammatory cascades. Translating these t

SUBMITTER: Jurcau A 

PROVIDER: S-EPMC10573049 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature