First-Row Transition Metal Complexes Incorporating the 2-(2'-pyridyl)quinoxaline Ligand (pqx), as Potent Inflammatory Mediators: Cytotoxic Properties and Biological Activities against the Platelet-Activating Factor (PAF) and Thrombin.

ABSTRACT: Inflammatory mediators constitute a recently coined term in the field of metal-based complexes with antiplatelet activities. Our strategy targets Platelet-Activating Factor (PAF) and its receptor, which is the most potent lipid mediator of inflammation. Thus, the antiplatelet (anti-PAF) potency of any substance could be exerted by inhibiting the PAF-induced aggregation in washed rabbit platelets (WRPs), which internationally is a well-accepted methodology. Herein, a series of mononuclear (mer-[Cr(pqx)Cl₃(H₂O]) (1), [Co(pqx)Cl₂(DMF)] (2) (DMF = N,N'-dimethyl formamide), [Cu(pqx)Cl₂(DMSO)] (3) (DMSO = dimethyl sulfoxide), [Zn(pqx)Cl₂] (4)) and dinuclear complexes ([Mn(pqx)(H₂O)<

SUBMITTER: Margariti A 

PROVIDER: S-EPMC10574351 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature