Associations of Alzheimer's-related plasma biomarkers with cognitive decline in Parkinson's disease.

ABSTRACT:

Background

Parkinson's disease (PD) is associated with cognitive decline through multiple mechanisms, including Alzheimer's disease (AD) pathology and cortical Lewy body involvement. However, its underlying mechanisms remain unclear. Recently, AD-related plasma biomarkers have emerged as potential tools for predicting abnormal pathological protein accumulation. We aimed to investigate the association between AD-related plasma biomarkers and cognitive decline in PD patients.

Methods

Plasma biomarkers were measured in 70 PD patients (49 with nondemented Parkinson's disease (PDND) and 21 with Parkinson's disease dementia (PDD)) and 38 healthy controls (HCs) using a single-molecule array. The study evaluated (1) the correlation between plasma biomarkers and clinical parameters,

SUBMITTER: Mizutani Y 

PROVIDER: S-EPMC10576723 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature