Plasma MIA, CRP, and Albumin Predict Cognitive Decline in Parkinson's Disease.

ABSTRACT:

Objective

Using a multi-cohort, discovery-replication-validation design, we sought new plasma biomarkers that predict which individuals with Parkinson's disease (PD) will experience cognitive decline.

Methods

In 108 discovery cohort PD individuals and 83 replication cohort PD individuals, we measured 940 plasma proteins on an aptamer-based platform. Using proteins associated with subsequent cognitive decline in both cohorts, we trained a logistic regression model to predict which patients with PD showed fast (> = 1 point drop/year on Montreal Cognitive Assessment [MoCA]) versus slow (< 1 point drop/year on MoCA) cognitive decline in the discovery cohort, testing it in the replication cohort. We developed alternate assays for the top 3 proteins and confirmed their ability to

SUBMITTER: Shen J 

PROVIDER: S-EPMC9329215 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature