Late permissive hypercapnia and respiratory stability among very preterm infants: a pilot randomised trial.

ABSTRACT:

Objective

Determine if targeting higher transcutaneous carbon dioxide improves respiratory stability among very preterm infants on ventilatory support.

Design

Single-centre pilot randomised clinical trial.

Setting

The University of Alabama at Birmingham.

Patients

Very preterm infants on ventilatory support after postnatal day 7.

Interventions

Infants were randomised to two different transcutaneous carbon dioxide levels targeting 5 mm Hg (0.67 kPa) changes with four sessions each lasting 24 hours for 96 hours: baseline-increase-baseline-increase or baseline-decrease-baseline-decrease.

Main outcome measures

We collected cardiorespiratory data evaluating episodes of intermittent hypoxaemia (oxygen saturations (SpO₂)<85% for ≥10 s), bradyca

SUBMITTER: Travers CP 

PROVIDER: S-EPMC10578058 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature