Gut virome profiling identifies an association between temperate phages and colorectal cancer promoted by Helicobacter pylori infection.

ABSTRACT: Colorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide. While a close correlation between chronic Helicobacter pylori infection and CRC has been reported, the role of the virome has been overlooked. Here, we infected Apc-mutant mouse models and C57BL/6 mice with H. pylori and conducted a comprehensive metagenomics analysis of H. pylori-induced changes in lower gastrointestinal tract bacterial and viral communities. We observed an expansion of temperate phages in H. pylori infected Apc^+/1638N mice at the early stage of carcinogenesis. Some of the temperate phages were predicted to infect bacteria associated with CRC, including Enterococcus faecalis. We also observed a high prevalence of virulent gene

SUBMITTER: Luo S 

PROVIDER: S-EPMC10578192 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature