Ontology highlight
ABSTRACT:
SUBMITTER: Elguero JE
PROVIDER: S-EPMC10579427 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Elguero Johnny E JE Liu Guangmei G Tiemeyer Katherine K Bandyadka Shruthi S Gandevia Heena H Duro Lauren L Yan Zhenhao Z McCall Kimberly K
iScience 20230926 10
In nervous system development, disease, and injury, neurons undergo programmed cell death, leaving behind cell corpses that are removed by phagocytic glia. Altered glial phagocytosis has been implicated in several neurological diseases including Alzheimer's disease. To untangle the links between glial phagocytosis and neurodegeneration, we investigated <i>Drosophila</i> mutants lacking the phagocytic receptor Draper. Loss of Draper leads to persistent neuronal cell corpses and age-dependent neur ...[more]