A preliminary transcriptomic analysis of the orbitofrontal cortex of antisocial individuals.

ABSTRACT:

Aims

Antisocial personality disorder (ASPD) and conduct disorder (CD) are characterized by a persistent pattern of violations of societal norms and others' rights. Ample evidence shows that the pathophysiology of these disorders is contributed by orbitofrontal cortex (OFC) alterations, yet the underlying molecular mechanisms remain elusive. To address this knowledge gap, we performed the first-ever RNA sequencing study of postmortem OFC samples from subjects with a lifetime diagnosis of ASPD and/or CD.

Methods

The transcriptomic profiles of OFC samples from subjects with ASPD and/or CD were compared to those of unaffected age-matched controls (n = 9/group).

Results

The OFC of ASPD/CD-affected subjects displayed significant differences in the expression of 328 genes. F

SUBMITTER: Piras IS 

PROVIDER: S-EPMC10580340 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature