Dataset Information

Iodine-Induced Hyperthyroidism and Long-term Risks of Incident Atrial Fibrillation and Flutter.

ABSTRACT:

Context

Although iodine-induced hyperthyroidism is a potential consequence of iodinated radiologic contrast administration, its association with long-term cardiovascular outcomes has not been previously studied.

Objective

To investigate the relationships between hyperthyroidism observed after iodine contrast administration and incident atrial fibrillation/flutter.

Methods

Retrospective cohort study of the U.S. Veterans Health Administration (1998-2021) of patients age ≥18 years with a normal baseline serum thyrotropin (TSH) concentration, subsequent TSH <1 year, and receipt of iodine contrast <60 days before the subsequent TSH. Cox proportional hazards regression was employed to ascertain the adjusted hazard ratio (HR) with 95% CI of incident atrial fibrillation/flutter following iodine-induced hyperthyroidism, compared with iodine-induced euthyroidism.

Results

Iodine-induced hyperthyroidism was observed in 2500 (5.6%) of 44 607 Veterans (mean ± SD age, 60.9 ± 14.1 years; 88% men) and atrial fibrillation/flutter in 10.4% over a median follow-up of 3.7 years (interquartile range 1.9-7.4). Adjusted for sociodemographic and cardiovascular risk factors, iodine-induced hyperthyroidism was associated with an increased risk of atrial fibrillation/flutter compared with those who remained euthyroid after iodine exposure (adjusted HR 1.19, 95% CI 1.06-1.33). Females were at greater risk for incident atrial fibrillation/flutter than males (females, HR 1.81, 95% CI 1.12-2.92; males, HR 1.15, 95% CI 1.03-1.30; P for interaction = .04).

Conclusion

Hyperthyroidism following a high iodine load was associated with an increased risk of incident atrial fibrillation/flutter, particularly among females. The observed sex-based differences should be confirmed in a more sex-diverse study sample, and the cost-benefit analysis of long-term monitoring for cardiac arrhythmias following iodine-induced hyperthyroidism should be evaluated.

SUBMITTER: Inoue K

PROVIDER: S-EPMC10584637 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Publications

Iodine-Induced Hyperthyroidism and Long-term Risks of Incident Atrial Fibrillation and Flutter.

Inoue Kosuke K Guo Rong R Lee Martin L ML Ebrahimi Ramin R Neverova Natalia V NV Currier Jesse W JW Bashir Muhammad T MT Leung Angela M AM

The Journal of clinical endocrinology and metabolism 20230901 10

<h4>Context</h4>Although iodine-induced hyperthyroidism is a potential consequence of iodinated radiologic contrast administration, its association with long-term cardiovascular outcomes has not been previously studied.<h4>Objective</h4>To investigate the relationships between hyperthyroidism observed after iodine contrast administration and incident atrial fibrillation/flutter.<h4>Methods</h4>Retrospective cohort study of the U.S. Veterans Health Administration (1998-2021) of patients age ≥18 y ...[more]

PMID: 37146179

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Dataset Information

Iodine-Induced Hyperthyroidism and Long-term Risks of Incident Atrial Fibrillation and Flutter.

Context

Objective

Methods

Results

Conclusion

Publications

Iodine-Induced Hyperthyroidism and Long-term Risks of Incident Atrial Fibrillation and Flutter.

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