Renal protection CT protocol using low-dose and low-concentration iodine contrast medium in at-risk patients of HCC and with chronic kidney disease: a randomized controlled non-inferiority trial.

ABSTRACT:

Background

Although efforts have been made to reduce the dose of Contrast Medium (CM) to improve patient safety, there are ongoing concerns regarding its potential effects on image quality and diagnostic performance. Moreover, research is lacking to establish a lower limit for safe and effective CM dose reduction. To determine whether the image quality of contrast-enhanced liver computed tomography (CT) using a reduced amount of iodinated CM was similar to that of standard liver CT.

Methods

We enrolled participants at risk for hepatocellular carcinoma with decreased estimated glomerular filtration rates (< 60 mL/min/1.73m²). Participants were randomly assigned to the standard group or the renal protection protocol (RPP) group. In the standard group, images were re

SUBMITTER: Yoon JH 

PROVIDER: S-EPMC10588122 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature