CC⁺ : A searchable database of validated coiled coils in PDB structures and AlphaFold2 models.

ABSTRACT: α-Helical coiled coils are common tertiary and quaternary elements of protein structure. In coiled coils, two or more α helices wrap around each other to form bundles. This apparently simple structural motif can generate many architectures and topologies. Coiled coil-forming sequences can be predicted from heptad repeats of hydrophobic and polar residues, hpphppp, although this is not always reliable. Alternatively, coiled-coil structures can be identified using the program SOCKET, which finds knobs-into-holes (KIH) packing between side chains of neighboring helices. SOCKET also classifies coiled-coil architecture and topology, thus allowing sequence-to-structure relationships to be garnered. In 2009, we used SOCKET to create a relational database of coiled-coil structures, CC⁺

SUBMITTER: Kumar P 

PROVIDER: S-EPMC10588367 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature