Genomic Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Isolated from Neonatal Patients in Southwest China During 2017-2021.

ABSTRACT:

Objective

Carbapenem-resistant Klebsiella pneumoniae (CRKP) is spreading worldwide, becoming a serious threat to public health. The present study aimed to analyze the molecular epidemiology and drug resistance mechanism of CRKP isolated from neonatal patients in Sichuan, Southwest China.

Methods

CRKP isolates were collected from neonatal patients of West China Second University Hospital from June 2017 to June 2021. Antimicrobial susceptibility testing was performed using broth microdilution. Whole-genome sequencing of all isolates were performed to determine the antimicrobial resistance genes, sequence typing, phylogenetic relationships.

Results

In total, 41 nonduplicate CRKP isolates were collected. All isolates were highly resistant to the cephalosporins and

SUBMITTER: Wu W 

PROVIDER: S-EPMC10590067 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature