Dataset Information

Association between light rare earth elements in maternal plasma and the risk of spontaneous preterm birth: a nested case-control study from the Beijing birth cohort study.

ABSTRACT:

Background

Parental exposure to rare earth elements (REEs) could increase the risk of premature rupture of membranes, a major cause of spontaneous preterm birth (SPB). In addition, different subtypes of SPB, such as spontaneous preterm labor (SPL) and preterm premature rupture of membranes (PPROM), may have different susceptibility to environmental exposure. Therefore, we investigated the potential associations between REE exposure in different trimesters and SPB and its subtypes.

Methods

A nested case-control study was performed. We included 244 women with SPB as cases and 244 women with full-term delivery as controls. The plasma concentrations of light REEs were measured in the first and third trimesters. Logistic regression was used to analyze the associations between single REE levels and SPB, and Bayesian kernel machine regression (BKMR) was used to analyze the mixed-exposure effect.

Results

Exposure to light REEs was associated with SPB and its subtypes only in the third trimester. Specifically, the intermediate- and highest-tertile concentration groups of La and the highest-tertile concentration group of Sm were associated with an increased risk of SPL, with adjusted odds ratios (AORs) of 2.00 (95% CIs: 1.07-3.75), 1.87 (95% CIs: 1.01-3.44), and 1.82 (95% CIs: 1.00-3.30), respectively. The highest-tertile concentration group of Pr was associated with an increased risk of PPROM, with an AOR of 1.69 (95% CIs: 1.00-2.85). Similar results were also found in BKMR models.

Conclusions

La and Sm levels in plasma may be associated with the risk of SPL, and Pr levels in plasma may be associated with the risk of PPROM.

SUBMITTER: Chen J

PROVIDER: S-EPMC10591387 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Publications

Association between light rare earth elements in maternal plasma and the risk of spontaneous preterm birth: a nested case-control study from the Beijing birth cohort study.

Chen Junxi J Wang Aili A An Hang H Han Weiling W Huang Junhua J Zheng Wei W Yan Lailai L Li Zhiwen Z Li Guanghui G

Environmental health : a global access science source 20231023 1

<h4>Background</h4>Parental exposure to rare earth elements (REEs) could increase the risk of premature rupture of membranes, a major cause of spontaneous preterm birth (SPB). In addition, different subtypes of SPB, such as spontaneous preterm labor (SPL) and preterm premature rupture of membranes (PPROM), may have different susceptibility to environmental exposure. Therefore, we investigated the potential associations between REE exposure in different trimesters and SPB and its subtypes.<h4>Met ...[more]

PMID: 37872585

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Project description:BackgroundThe relationship between prenatal phthalate exposure and preterm birth from previous studies has been inconsistent. Meanwhile, few studies have explored the relationship between spontaneous preterm birth (SPTB) and genetic polymorphisms of metabolic enzyme genes or gene-phthalate interactions. The aim of this study is to evaluate the association of maternal phthalate exposure, genetic polymorphisms, and their interactions with SPTB.MethodsA total of 182 cases with SPTB and 321 controls with full-term delivery were enrolled. Nine phthalate metabolites in maternal second trimester urine samples were measured by ultra-high performance liquid chromatography coupled with tandem mass spectrometry. Genotyping was performed on twenty-six single nucleotide polymorphisms (SNPs) of metabolic enzyme genes, including CYP2C9, CYP2C19, UGT1A7, UGT2B7 and UGT2B15 genes. The associations between maternal phthalate exposure or genetic polymorphisms and SPTB were estimated by multivariable logistic regression analysis. The impact of interactions between gene-gene and gene-phthalate exposure on SPTB were analyzed via generalized multifactor dimensionality reduction.ResultsThere were no significant differences in the concentrations of phthalate metabolites between the two groups. No statistically significant associations were observed between maternal phthalate exposure and SPTB. The rs4244285 polymorphism of CYP2C19 gene was associated with decreased odds of SPTB under the log-additive (aOR = 0.73, 95% CI: 0.55-0.98) and recessive model (aOR = 0.37, 95% CI: 0.18-0.74). Two SNP loci of UGT2B15 were associated with increased odds of SPTB under the recessive genetic model (aOR = 3.85, 95% CI: 1.31-11.35 for rs3100, and aOR = 3.85, 95% CI: 1.31-11.35 for rs4148269). However, these associations were not significant after the false discovery rate correction. No significant gene-gene or gene-phthalate metabolites interactions for SPTB were observed.ConclusionsMaternal phthalate exposure in the present subjects and genetic polymorphisms of metabolic enzyme genes were not associated with SPTB. Moreover, there were no significant gene-gene or gene-phthalates interactions for SPTB.

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Dataset Information

Association between light rare earth elements in maternal plasma and the risk of spontaneous preterm birth: a nested case-control study from the Beijing birth cohort study.

Background

Methods

Results

Conclusions

Publications

Association between light rare earth elements in maternal plasma and the risk of spontaneous preterm birth: a nested case-control study from the Beijing birth cohort study.

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