The impact of pubertal stress and adult hormone exposure on the transcriptome of the developing hypothalamus.

ABSTRACT: Why individuals suffer negative consequences following stress is a complex phenomenon that is dictated by individual factors, the timing of stress within the lifespan, and when in the lifespan the consequences are measured. Women who undergo adverse childhood experiences are at risk for lasting biological consequences, including affective and stress dysregulation. We have shown that pubertal adversity is associated with a blunted hypothalamic-pituitary-adrenal axis glucocorticoid response in peripartum humans and mice. In mice, our prior examination of the paraventricular nucleus (PVN) of the hypothalamus showed that pubertal stress led to an upregulation of baseline mRNA expression of six immediate early genes (IEGs) in the PVN of adult, pregnant mice. Separately, we showed that the pregn

SUBMITTER: Gautier KN 

PROVIDER: S-EPMC10592881 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature