Ontology highlight
ABSTRACT:
SUBMITTER: Hachey SJ
PROVIDER: S-EPMC10593408 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Hachey Stephanie J SJ Sobrino Agua A Lee John G JG Jafari Mehraneh D MD Klempner Samuel J SJ Puttock Eric J EJ Edwards Robert A RA Lowengrub John S JS Waterman Marian L ML Zell Jason A JA Hughes Christopher C W CCW
Translational research : the journal of laboratory and clinical medicine 20221205
Accurately modeling tumor biology and testing novel therapies on patient-derived cells is critically important to developing therapeutic regimens personalized to a patient's specific disease. The vascularized microtumor (VMT), or "tumor-on-a-chip," is a physiologic preclinical cancer model that incorporates key features of the native human tumor microenvironment within a transparent microfluidic platform, allowing rapid drug screening in vitro. Herein we optimize methods for generating patient-d ...[more]