Unknown

Dataset Information

0

Analysis of the relationship between sleep-related disorder and systemic immune-inflammation index in the US population.


ABSTRACT:

Background

The association between sleep-related disorders and inflammation has been demonstrated in previous studies. The systemic immune-inflammation index (SII) is a novel inflammatory index based on leukocytes, but its relationship with sleep-related disorder is unclear. We aimed to investigate the relationship between sleep-related disorder and SII in a nationally representative nonhospitalized sample.

Methods

Data were obtained from the 2005-2008 National Health and Nutrition Examination Survey (NHANES). Exposure variables included self-reported sleep-related disorders, such as sleep duration, sleep problems, high risk of OSA, and daytime sleepiness. SII and other traditional markers of inflammation were considered as outcome variables, including platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR). Multiple linear regression models were employed to examine the correlation between sleep-related disorders and inflammatory markers. Subgroup interactions were analyzed using likelihood ratio tests, and nonlinear relationships were explored by fitting restricted cubic splines.

Results

A total of 8,505 participants were enrolled in this study. Overall, sleep-related disorders were found to have a stronger association with SII compared to the PLR and NLR. The results of multiple linear regression analysis revealed that participants who experienced sleep problems (β: 21.421; 95% CI 1.484, 41.358), had symptoms of OSA (β: 23.088; 95% CI 0.441, 45.735), and reported daytime sleepiness (β: 30.320; 95% CI 5.851, 54.789) exhibited a positive association with higher SII. For the analysis of other inflammatory markers, we only found that daytime sleepiness was associated with increased NLR levels (β: 0.081; 95% CI 0.002, 0.159).

Conclusion

Sleep problems, symptoms of OSA, and daytime sleepiness were found to have a positive association with the SII in US adults. However, further prospective studies are necessary to establish whether there is a causal relationship between these factors.

SUBMITTER: Kadier K 

PROVIDER: S-EPMC10594811 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Analysis of the relationship between sleep-related disorder and systemic immune-inflammation index in the US population.

Kadier Kaisaierjiang K   Dilixiati Diliyaer D   Ainiwaer Aikeliyaer A   Liu Xiaozhu X   Lu Jiande J   Liu Pengfei P   Ainiwan Mierxiati M   Yesitayi Gulinazi G   Ma Xiang X   Ma Yitong Y  

BMC psychiatry 20231024 1


<h4>Background</h4>The association between sleep-related disorders and inflammation has been demonstrated in previous studies. The systemic immune-inflammation index (SII) is a novel inflammatory index based on leukocytes, but its relationship with sleep-related disorder is unclear. We aimed to investigate the relationship between sleep-related disorder and SII in a nationally representative nonhospitalized sample.<h4>Methods</h4>Data were obtained from the 2005-2008 National Health and Nutritio  ...[more]

Similar Datasets

| S-EPMC10493082 | biostudies-literature
| S-EPMC10179406 | biostudies-literature
| S-EPMC10852278 | biostudies-literature
| S-EPMC10416535 | biostudies-literature
| S-EPMC11349521 | biostudies-literature
| S-EPMC11663310 | biostudies-literature
| S-EPMC11218411 | biostudies-literature
| S-EPMC10806274 | biostudies-literature
| S-EPMC9529965 | biostudies-literature