Nascent transcription upon interferon-α2 stimulation on human and rhesus macaque lymphoblastoid cell lines.

ABSTRACT:

Objectives

The interferon-triggered innate immune response has been observed to be under strong diversifying selection to counteract the many pathogens hosts have to defend against. In particular, rewiring of gene transcription regulation allows organisms to rapidly acquire new phenotypes by removing and adding genes into the innate immune gene network. Dissecting the molecular processes by which this rewiring takes place, either by changing the DNA regulatory elements or by changing the activity of the regulators across species, is key to better understand this evolutionary process.

Data description

To better comprehend the evolutionary dynamics that have occurred in the initial transcriptional response to interferon in primates, we present Precision Run-On (PRO-seq) datase

SUBMITTER: Ramirez D 

PROVIDER: S-EPMC10604760 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature