Bovine oviductal organoids: a multi-omics approach to capture the cellular and extracellular molecular response of the oviduct to heat stress.

ABSTRACT:

Background

The mammalian oviduct is a complex, fibromuscular organ known for its role in orchestrating a series of timely and dynamic changes to suitably support early embryogenesis. Climate change-induced heat stress (HS) is one of the largest single stressors compromising reproductive function in humans and farm animals via systemic changes in the redox status of the maternal environment, adversely affecting fertilization and early embryonic development. Oviductal organoids represent a unique 3-dimensional, biomimetic model to study the physiology of the oviduct and its subsequent impact on embryo development under various environmental conditions.

Results

Our study is the first to demonstrate an innovative approach to understanding the cascade of molecular changes sustain

SUBMITTER: Menjivar NG 

PROVIDER: S-EPMC10605953 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature