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Crystal Structure and Intermolecular Energy for Some Nandrolone Esters.

ABSTRACT: Nandrolone (Estr-4-en-17β-ol-3-one) is a derivative of testosterone and a naturally occurring anabolic-androgenic agent which belongs to the steroid group. Crystal structures of four short, medium and long esterified forms of nandrolone, including propionate, phenylpropionate, cypionate and undecanoate were determined using single-crystal X-ray diffraction. Crystal packing, supramolecular features and intermolecular interactions were described based on a quantitative and qualitative Hirshfeld surfaces analysis accompanied by evaluation of crystal energies and intermolecular interactions computation. Also, the solubility of the esters was investigated from a pharmaceutical perspective.

SUBMITTER: Mare L

PROVIDER: S-EPMC10609429 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Crystal Structure and Intermolecular Energy for Some Nandrolone Esters.

Mare Liviu L Muresan-Pop Marieta M Purcea Lopes Pompilia Mioara PM Turza Alexandru A Borodi Gheorghe G Popescu Violeta V

Molecules (Basel, Switzerland) 20231019 20

Nandrolone (Estr-4-en-17β-ol-3-one) is a derivative of testosterone and a naturally occurring anabolic-androgenic agent which belongs to the steroid group. Crystal structures of four short, medium and long esterified forms of nandrolone, including propionate, phenylpropionate, cypionate and undecanoate were determined using single-crystal X-ray diffraction. Crystal packing, supramolecular features and intermolecular interactions were described based on a quantitative and qualitative Hirshfeld su ...[more]

PMID: 37894658

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2023-11-29 | GSE233177 | GEO

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