How Does CBG Administration Affect Sphingolipid Deposition in the Liver of Insulin-Resistant Rats?

ABSTRACT:

Background

Cannabigerol (CBG), a non-psychotropic phytocannabinoid found in Cannabis sativa plants, has been the focus of recent studies due to its potential therapeutic properties. We proposed that by focusing on sphingolipid metabolism, which plays a critical role in insulin signaling and the development of insulin resistance, CBG may provide a novel therapeutic approach for metabolic disorders, particularly insulin resistance.

Methods

In a rat model of insulin resistance induced by a high-fat, high-sucrose diet (HFHS), we aimed to elucidate the effect of intragastrically administered CBG on hepatic sphingolipid deposition and metabolism. Moreover, we also elucidated the expression of sphingolipid transporters and changes in the sphingolipid concentration in the pla

SUBMITTER: Bzdega W 

PROVIDER: S-EPMC10609522 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature