IRF1 regulates self-renewal and stress responsiveness to support hematopoietic stem cell maintenance.

ABSTRACT: Hematopoietic stem cells (HSCs) are tightly controlled to maintain a balance between blood cell production and self-renewal. While inflammation-related signaling is a critical regulator of HSC activity, the underlying mechanisms and the precise functions of specific factors under steady-state and stress conditions remain incompletely understood. We investigated the role of interferon regulatory factor 1 (IRF1), a transcription factor that is affected by multiple inflammatory stimuli, in HSC regulation. Our findings demonstrate that the loss of IRF1 from mouse HSCs significantly impairs self-renewal, increases stress-induced proliferation, and confers resistance to apoptosis. In addition, given the frequent abnormal expression of IRF1 in leukemia, we explored the potential of IRF1

SUBMITTER: Rundberg Nilsson AJS 

PROVIDER: S-EPMC10610924 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature