Mucosal expression of PI3, ANXA1, and VDR discriminates Crohn's disease from ulcerative colitis.

ABSTRACT: Differential diagnosis of inflammatory bowel disease (IBD) to Crohn's disease (CD) or ulcerative colitis (UC) is crucial for treatment decision making. With the aim of generating a clinically applicable molecular-based tool to classify IBD patients, we assessed whole transcriptome analysis on endoscopy samples. A total of 408 patient samples were included covering both internal and external samples cohorts. Whole transcriptome analysis was performed on an internal cohort of FFPE IBD samples (CD, n = 16 and UC, n = 17). The 100 most significantly differentially expressed genes (DEG) were tested in two external cohorts. Ten of the DEG were further processed by functional enrichment analysis from which seven were found to show consistent significant performance in discriminating CD from UC: P

SUBMITTER: James JP 

PROVIDER: S-EPMC10611705 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature