Increased collective migration correlates with germline stem cell competition in a basal chordate.

ABSTRACT: Cell competition is a process that compares the relative fitness of progenitor cells, resulting in winners, which contribute further to development, and losers, which are excluded, and is likely a universal quality control process that contributes to the fitness of an individual. Cell competition also has pathological consequences, and can create super-competitor cells responsible for tumor progression. We are studying cell competition during germline regeneration in the colonial ascidian, Botryllus schlosseri. Germline regeneration is due to the presence of germline stem cells (GSCs) which have a unique property: a competitive phenotype. When GSCs from one individual are transplanted into another, the donor and recipient cells compete for germline development. Often the donor GSCs win, an

SUBMITTER: Fentress MK 

PROVIDER: S-EPMC10615308 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature