Antileishmanial activity of 5-nitroindazole derivatives.

ABSTRACT:

Background

Currently, there is no safe and effective vaccine against leishmaniasis and existing therapies are inadequate due to high toxicity, cost and decreased efficacy caused by the emergence of resistant parasite strains. Some indazole derivatives have shown in vitro and in vivo activity against Trichomonas vaginalis and Trypanosoma cruzi. On that basis, 20 indazole derivatives were tested in vitro against Leishmania amazonensis.

Objective

To evaluate the in vitro activity of twenty 2-benzyl-5-nitroindazolin-3-one derivatives against L. amazonensis.

Design

For the selection of promising compounds, it is necessary to evaluate the indicators for in vitro activity. For this aim, a battery of studies for a

SUBMITTER: Mollineda-Diogo N 

PROVIDER: S-EPMC10617274 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature