Hydrogen sulfide and polysulfides induce GABA/glutamate/D-serine release, facilitate hippocampal LTP, and regulate behavioral hyperactivity.

ABSTRACT: Hydrogen sulfide (H₂S) and polysulfides (H₂S_n, n ≥ 2) are signaling molecules produced by 3-mercaptopyruvate sulfurtransferase (3MST) that play various physiological roles, including the induction of hippocampal long-term potentiation (LTP), a synaptic model of memory formation, by enhancing N-methyl-D-aspartate (NMDA) receptor activity. However, the presynaptic action of H₂S/H₂S_n on neurotransmitter release, regulation of LTP induction, and animal behavior are poorly understood. Here, we showed that H₂S/H₂S₂ applied to the rat hippocampus by in vivo microdialysis induces the release of GABA, glutamate, and D-serine, a co-agonist of NMDA receptors. Animals with genetically knocked-out 3MST an

SUBMITTER: Furuie H 

PROVIDER: S-EPMC10618189 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature