Late I_Na Blocker GS967 Supresses Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long QT Type 2.

ABSTRACT:

Background

Long QT syndrome has been associated with sudden cardiac death likely caused by early afterdepolarizations (EADs) and polymorphic ventricular tachycardias (PVTs). Suppressing the late sodium current (I_NaL) may counterbalance the reduced repolarization reserve in long QT syndrome and prevent EADs and PVTs.

Methods

We tested the effects of the selective I_NaL blocker GS967 on PVT induction in a transgenic rabbit model of long QT syndrome type 2 using intact heart optical mapping, cellular electrophysiology and confocal Ca²⁺ imaging, and computer modeling.

Results

GS967 reduced ventricular fibrillation induction under a rapid pacing protocol (n=7/14 hearts in control versus 1/14 hearts at 100 nmol/L) without altering action pote

SUBMITTER: Hwang J 

PROVIDER: S-EPMC10626560 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature