β-adrenergic signaling triggers enteric glial reactivity and acute enteric gliosis during surgery.

ABSTRACT:

Background

Enteric glia contribute to the pathophysiology of various intestinal immune-driven diseases, such as postoperative ileus (POI), a motility disorder and common complication after abdominal surgery. Enteric gliosis of the intestinal muscularis externa (ME) has been identified as part of POI development. However, the glia-restricted responses and activation mechanisms are poorly understood. The sympathetic nervous system becomes rapidly activated by abdominal surgery. It modulates intestinal immunity, innervates all intestinal layers, and directly interfaces with enteric glia. We hypothesized that sympathetic innervation controls enteric glia reactivity in response to surgical trauma.

Methods

Sox10^iCreERT2/Rpl22^HA/+ mice were subjected to a mous

SUBMITTER: Leven P 

PROVIDER: S-EPMC10631040 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature