Anti-angiogenic therapies in the management of glioblastoma.
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ABSTRACT:
SUBMITTER: Schulte JD
PROVIDER: S-EPMC10631456 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Publications
Anti-angiogenic therapies in the management of glioblastoma.
Schulte Jessica D JD Aghi Manish K MK Taylor Jennie W JW
Chinese clinical oncology 20200421 4
Angiogenesis is a central feature of glioblastoma (GBM), with contribution from several mechanisms and signaling pathways to produce an irregular, poorly constructed, and poorly connected tumor vasculature. Targeting angiogenesis has been efficacious for disease control in other cancers, and given the (I) highly vascularized environment in GBM and (II) correlation between glioma grade and prognosis, angiogenesis became a prime target of therapy in GBM as well. Here, we discuss the therapies deve ...[more]
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