Circulating Osteoprogenitor Cells Have a Mixed Immune and Mesenchymal Progenitor Function in Humans.

ABSTRACT:

Background

Circulating osteoprogenitors (COP) are a population of cells in the peripheral circulation that possess functional and phenotypical characteristics of multipotent stromal cells (MSCs). This population has a solid potential to become an abundant, accessible, and replenishable source of MSCs with multiple potential clinical applications. However, a comprehensive functional characterization of COP cells is still required to test and fully develop their use in clinical settings.

Methods

This study characterized COP cells by comparing them to bone marrow-derived MSCs (BM-MSCs) and adipose-derived MSCs (ASCs) through detailed transcriptomic and proteomic analyses.

Results

We demonstrate that COP cells have a distinct gene and protein expression pattern with a sig

SUBMITTER: Feehan J 

PROVIDER: S-EPMC10631805 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature