QUFIND: tool for comparative prediction and mining of G4 quadruplexes overlapping with CpG islands.

ABSTRACT: G-quadruplexes (G4s) are secondary structures in DNA that have been shown to be involved in gene regulation. They play a vital role in the cellular processes and several pathogens including bacteria, fungi, and viruses have also been shown to possess G4s that help them in their pathogenesis. Additionally, cross-talk among the CpG islands and G4s has been shown to influence biological processes. The virus-encoded G4s are affected by the mutational landscape leading to the formation/deletion of these G4s. Therefore, understanding and predicting these multivariate effects on traditional and non-traditional quadruplexes forms an important area of research, that is, yet to be investigated. We have designed a user-friendly webserver QUFIND (http://soodlab.com/qufinder/) that can predict traditio

SUBMITTER: Kaur B 

PROVIDER: S-EPMC10634401 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature