Mice identify subgoal locations through an action-driven mapping process.
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ABSTRACT:
SUBMITTER: Shamash P
PROVIDER: S-EPMC10636595 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
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Mice identify subgoal locations through an action-driven mapping process.
Shamash Philip P Lee Sebastian S Saxe Andrew M AM Branco Tiago T
Neuron 20230428 12
Mammals form mental maps of the environments by exploring their surroundings. Here, we investigate which elements of exploration are important for this process. We studied mouse escape behavior, in which mice are known to memorize subgoal locations-obstacle edges-to execute efficient escape routes to shelter. To test the role of exploratory actions, we developed closed-loop neural-stimulation protocols for interrupting various actions while mice explored. We found that blocking running movements ...[more]
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