T2SS-peptidase XcpA associated with LasR evolutional phenotypic variations provides a fitness advantage to Pseudomonas aeruginosa PAO1.

ABSTRACT: The Gram-negative opportunistic pathogen Pseudomonas aeruginosa possesses hierarchical quorum sensing (QS) systems. The intricate QS network of P. aeruginosa synchronizes a suite of virulence factors, contributing to the mortality and morbidity linked to the pathogenicity of this bacterium. Previous studies have revealed that variations in the lasR gene are frequently observed in chronic isolates of cystic fibrosis (CF). Specifically, LasR^Q45stop was identified as a common variant among CF, lasR mutants during statistical analysis of the clinical lasR mutants in the database. In this study, we introduced LasR^Q45stop into the chromosome of P. aeruginosa PAO1 through allelic replacement. The social traits of PAO1 LasR^Q45sto

SUBMITTER: Cheng M 

PROVIDER: S-EPMC10637944 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature