Exploration of glycosyltransferases mutation status in cervical cancer reveals PARP14 as a potential prognostic marker.

ABSTRACT: This study investigates the potential role of Glycosyltransferases (GTs) in the glycosylation process and their association with malignant tumors. Specifically, the study focuses on PARP14, a member of GTs, and its potential as a target for tumors in the diagnosis and treatment of cervical cancer. To gather data, the study used somatic mutation data, gene expression data and clinical information from TCGA-CESE dataset as well as tissue samples from cervical cancer patients. Further verification was conducted through RT-qPCR and immunohistochemistry staining on cervical cancer tissues to confirm the expression of PARP14. The study utilized Kaplan-Meier for survival analysis of cervical cancer patient and found significant mutational abnormalities in GTs. The high frequency mutated gene was

SUBMITTER: Wang H 

PROVIDER: S-EPMC10638145 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature