Dataset Information

Reference intervals of complete blood count and coagulation tests in Vietnamese pregnant women.

ABSTRACT:

Background

Pregnancy has major effects that make hematology parameters outside of normal reference ranges. Therefore, we conducted this study to establish reference intervals for Vietnamese pregnant women.

Methods

From June 2023 to Augst 2023, blood samples from 879 eligible pregnant women were run on DxH 900 hematology analyzer and ACL TOP 550 coagulation analyzer. The tested parameters are prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), white blood cell (WBC) and its differentials (neutrophils, lymphocytes, monocytes, eosinophils and basophils), red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), RBC distribution width (RDW), RBC distribution width standard deviation (RDW-SD), platelet count (PLT), mean platelet volume (MPV). A non-parametric method was used to establish the 2.5^th and 97.5^th percentile reference intervals.

Results

PT, APTT decrease but fibrinogen increases during pregnancy. Physiological adaptations of pregnancy result in a decrease in RBC count, but an increase in WBC count and no changes in platelet count. The reference intervals for PT (seconds), APTT (seconds), fibrinogen (mg/dL), in the first trimester were 10.30-12.88, 25.40-35.46, 280.28-559.00, in the second trimester were 9.80-11.66, 24.05-33.23, 347.75-593.35, in the third trimester were 9.60-11.40, 23.40-31.80, 330.28-628.56, respectively. The reference intervals for main hematology parameters which are WBC (× 10⁹/L), RBC (× 10¹²/L), HGB (g/dL), HCT (%), PLT (× 10⁹/L) in the first trimester were 6.33-15.24, 3.73-5.32, 10.33-13.95, 32.22-42.29, 169.66-413.88, in the second trimester were 6.99-15.55, 3.33-4.98, 9.71-13.17, 30.26-40.07, 172.34-372.19, in the third trimester were 6.22-14.14, 3.54-4.98, 9.80-13.97, 31.11-42.70, 151.30-417.14, respectively.

Conclusions

Most established referenced intervals from each trimester differ from other trimesters. These trimester-specific reference ranges for Vietnamese pregnant women will aid clinicians in entepreting parameters and help other laboratories adopt these ranges after validating.

Trial registration

This study is registered at www.

Clinicaltrials

gov as NCT05929326.

SUBMITTER: Pham HN

PROVIDER: S-EPMC10638750 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Publications

Reference intervals of complete blood count and coagulation tests in Vietnamese pregnant women.

Pham Huan Nguyen HN Huynh Nghiem Xuan NX Pham Phuc Nguyen Huu PNH Dang Dung Ngoc Yen DNY Cao Long Thang LT Huynh Diem Minh DM Thoi Hau Thi Thu HTT Le Oanh Hoang OH Beaupha Suzanne Monivong Cheanh SMC

BMC pregnancy and childbirth 20231111 1

<h4>Background</h4>Pregnancy has major effects that make hematology parameters outside of normal reference ranges. Therefore, we conducted this study to establish reference intervals for Vietnamese pregnant women.<h4>Methods</h4>From June 2023 to Augst 2023, blood samples from 879 eligible pregnant women were run on DxH 900 hematology analyzer and ACL TOP 550 coagulation analyzer. The tested parameters are prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), whi ...[more]

PMID: 37951881

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Dataset Information

Reference intervals of complete blood count and coagulation tests in Vietnamese pregnant women.

Background

Methods

Results

Conclusions

Trial registration

Clinicaltrials

Publications

Reference intervals of complete blood count and coagulation tests in Vietnamese pregnant women.

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