Investigating altered brain functional hubs and causal connectivity in coronary artery disease with cognitive impairment.

ABSTRACT:

Background

Coronary artery disease (CAD) and cognitive impairment (CI) have become significant global disease and medical burdens. There have been several reports documenting the alterations in regional brain function and their correlation with CI in CAD patients. However, there is limited research on the changes in brain network connectivity in CAD patients. To investigate the resting-state connectivity and further understand the effective connectivity strength and directionality in patients with CAD, we utilized degree centrality (DC) and spectral dynamic causal modeling (spDCM) to detect functional hubs in the whole brain network, followed by an analysis of directional connections. Using the aforementioned approaches, it is possible to investigate the hub regions and aberrant co

SUBMITTER: Qin R 

PROVIDER: S-EPMC10640849 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature