The slan antigen identifies the prototypical non-classical CD16⁺-monocytes in human blood.

ABSTRACT:

Introduction

Peripheral monocytes in humans are conventionally divided into classical (CL, CD14⁺⁺CD16^-), intermediate (INT, CD14⁺⁺CD16⁺) and non-classical (NC, CD14^dim/-CD16⁺⁺) cells, based on their expression levels of CD14 and CD16. A major fraction of the NC-monocytes has been shown to express the 6-sulfo LacNAc (slan) antigen, but whether these slan⁺/NC-monocytes represent the prototypical non-classical monocytes or whether they are simply a sub-fraction with identical features as the remainder of NC monocytes is still unclear.

Methods

We analyzed transcriptome (by bulk and single cell RNA-seq), proteome, cell surface markers and production of discrete cytokines by peripheral slan⁺/NC

SUBMITTER: Tamassia N 

PROVIDER: S-EPMC10641684 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature