Genetic evidence for the causal association between type 1 diabetes and the risk of polycystic ovary syndrome.

ABSTRACT:

Background

Accumulating observational studies have identified associations between type 1 diabetes (T1D) and polycystic ovary syndrome (PCOS). Still, the evidence about the causal effect of this association is uncertain.

Methods

We performed a two-sample Mendelian randomization (MR) analysis to test for the causal association between T1D and PCOS using data from a large-scale biopsy-confirmed genome-wide association study (GWAS) in European ancestries. We innovatively divided T1D into nine subgroups to be analyzed separately, including: type1 diabetes wide definition, type1 diabetes early onset, type 1 diabetes with coma, type 1 diabetes with ketoacidosis, type 1 diabetes with neurological complications, type 1 diabetes with ophthalmic complications, type 1 diabetes with per

SUBMITTER: Chen S 

PROVIDER: S-EPMC10641977 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature