First evidence of genetic association between AKT2 and polycystic ovary syndrome.

ABSTRACT:

Objective

Insulin resistance has been reported in up to 70% of women with polycystic ovary syndrome (PCOS). Physiologic and genetic data currently implicate post-insulin receptor signaling defects in substrates such as glycogen synthase kinase 3beta (GSK3beta). The AKT2 gene was chosen as a candidate for PCOS because its product affects glucose metabolism and mitogenic signaling, interacts with GSK3beta, and mediates cell survival in the ovary.

Research design and methods

Subjects were recruited from the reproductive endocrinology clinic at the University of Alabama at Birmingham, and control subjects were recruited from the surrounding community; 287 white women with PCOS and 187 white control subjects were genotyped for four single nucleotide polymorphisms (SNPs) in AKT2.

SUBMITTER: Goodarzi MO 

PROVIDER: S-EPMC2584182 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature