Dataset Information

Children with intestinal failure are at risk for psychopathology and trauma.

ABSTRACT:

Objectives

To assess psychopathology and medical traumatic stress in children with intestinal failure (IF) and identify associated risk factors.

Methods

Two-center study, performed from September 2019 until April 2022 (partly during COVID-19 pandemic), including children (1.5-17y) with IF, dependent on parenteral nutrition (PN) or weaned off PN, treated by a multidisciplinary IF-team. Psychopathology in children was evaluated with a semi-structured interview assessing psychiatric classifications and validated questionnaires assessing emotional (internalizing) and behavioral (externalizing) problems. Medical traumatic stress was assessed with a validated questionnaire. Problem scores were compared with normative data. Associations between clinical characteristics and outcomes were analyzed with linear regression analyses.

Results

Forty-one (of 111 eligible) children were included (median age 8.9y (IQR 5.5-11.8), 54% female, 73% born preterm). Median PN-duration was 17.3 months (IQR 6.9-54.0); 17 children (41%) were still PN-dependent. One third of the children met criteria for at least one psychiatric classification (compared with 14% in age-matched general population). Anxiety disorders and attention deficit hyperactivity disorder were most common. In school-aged children (n=29, 6-17y), significantly increased emotional problems were consistently reported by children (p=0.011), parents (p<0.001) and teachers (p=0.004). In preschool children (n=12, 1.5-5y), no significant differences with normative data were found. Subclinical or clinical emotional problems were reported in 19 children (46%). Medical traumatic stress was present in 14%, and 22% of children had received psychological help for trauma before. Lower gastrointestinal related quality of life was associated with more emotional problems, but not PN-duration.

Conclusions

Children with IF, particularly school-aged children, are at risk for psychological problems which is reflected by the high rate of received psychotherapy and the high rate of emotional problems and psychiatric classifications.

SUBMITTER: Vlug LE

PROVIDER: S-EPMC10642705 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Publications

Children with Intestinal Failure are at Risk for Psychopathology and Trauma.

Vlug Lotte E LE Legerstee Jeroen S JS Tabbers Merit M MM Demirok Aysenur A Verloop Merel W MW Bosman Lotte L Rings Edmond H H M EHHM Wijnen René M H RMH Spoel Marjolein M de Koning Barbara A E BAE

Journal of pediatric gastroenterology and nutrition 20230908 6

<h4>Objectives</h4>The objective of this study is to assess the psychopathology and medical traumatic stress in children with intestinal failure (IF) and identify associated risk factors.<h4>Methods</h4>Two-center study, performed from September 2019 until April 2022 (partly during COVID-19 pandemic), including children (1.5-17 years) with IF, dependent on parenteral nutrition (PN) or weaned off PN, treated by a multidisciplinary IF-team. Psychopathology in children was evaluated with a semi-str ...[more]

PMID: 37679874

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