Dysbiosis of the gut microbiota as a susceptibility factor for Kawasaki disease.

ABSTRACT:

Introduction

Gut microbial imbalance (dysbiosis) has been reported in patients with acute Kawasaki disease (KD). However, no studies have analyzed the gut microbiota while focusing on susceptibility to KD. This study aimed to evaluate whether dysbiosis elevates susceptibility to KD by assessing children with a history of KD.

Methods

Fecal DNA was extracted from 26 children with a history of KD approximately 1 year prior (KD group, 12 boys; median age, 32.5 months; median time from onset, 11.5 months) and 57 age-matched healthy controls (HC group, 35 boys; median age, 36.0 months). 16S rRNA gene analysis was conducted with the Illumina Miseq instrument. Sequence reads were analyzed using QIIME2.

Results

For alpha diversity, Faith's phylogenetic diversity was significan

SUBMITTER: Teramoto Y 

PROVIDER: S-EPMC10644744 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature