Mendelian Randomization Analysis of Genetic Proxies of Thiazide Diuretics and the Reduction of Kidney Stone Risk.

ABSTRACT:

Importance

Clinical trial data have called into question the efficacy of thiazide diuretics for the prevention of kidney stones.

Objective

To identify whether there is an association between genetic proxies of thiazide diuretics and the risk of kidney stones.

Design, setting, and participants

This genetic association study undertook a mendelian randomization analysis of derived exposures and outcomes from genome-wide association study summary statistics. Genetic proxies of thiazide diuretics were derived from the International Consortium for Blood Pressure. Kidney stone cases and controls were derived from the Million Veteran Program, UK Biobank, and the FinnGen study. These cross-sectional designs do not report a duration of follow-up. Data analysis was performed in

SUBMITTER: Triozzi JL 

PROVIDER: S-EPMC10646726 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature