Integrated transcriptomics reveals the brain and blood biomarkers in Alzheimer's disease.

ABSTRACT:

Background

The systematic molecular associations between the peripheral blood cells and brain in Alzheimer's disease (AD) remains unclear, which hinders our understanding of AD pathological mechanisms and the exploration of new diagnostic biomarkers.

Methods

Here, we performed an integrated analysis of the brain and peripheral blood cells transcriptomics to establish peripheral biomarkers of AD. By employing multiple statistical analyses plus machine learning, we identified and validated multiple regulated central and peripheral network in patients with AD.

Results

By bioinformatics analysis, a total of 243 genes were differentially expressed in the central and peripheral systems, mainly enriched in three modules: immune response, glucose metabolism and lysosome. In a

SUBMITTER: Yu H 

PROVIDER: S-EPMC10651972 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature