Surgical treatment of tertiary hyperparathyroidism: does one fit for all?

ABSTRACT:

Background

Tertiary hyperparathyroidism (3HPT) is defined as a condition of excessive autonomous excretion of intact parathyroid hormone (iPTH) with persistent hypercalcemia (>10.5 mg/dL) that lasts for more than 12 months after a successful kidney transplantation, in the context of a long course secondary hyperparathyroidism (2HPT). The chronic high levels of iPTH cause a worsening of graft function, accompanied by systemic symptoms of hypercalcemia. The only curative therapy is parathyroidectomy (PTX). It remains unclear whether total parathyroidectomy with autotransplantation (TPTX-AT) or subtotal parathyroidectomy (SPTX) lead to better outcomes.

Aims

The aim of this retrospective, single-institution cohort study is to evaluate the rate of persistent or recurrent disease

SUBMITTER: Casella C 

PROVIDER: S-EPMC10652876 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature